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Dr. Oz Supplement Round-up: Caraway Seeds, Raspberry Ketone, 7-Keto, Forskolin, Saffron

Posted on April 17th, 2012 by Matt Schoeneberger

Dr. Oz puts out a lot of information in a week’s time, so much so that you have to wonder if there really is that much to talk about. If you took every supplement he recommended you’d have a cabinet full of pill bottles and powders and you’d be broke in a hurry. The unfortunate thing is that sometimes a good, science-backed supplement gets lumped in with all the nonsense and gets lost in the shuffle. In other words, a supplement that could actually help you get healthier gets the same air time as all the other garbage supplements. How are you supposed to know which ones are worth the money and which ones are not? Well, that’s where we come in.

Before you read about the supplements below, keep in mind that we’re going to be discussing the scientific evidence for these supplements, if there is any. This can sometimes include some technical jargon that might get a bit confusing. Don’t worry, we’ll have a general recommendation for each supplement that will help you if you get lost in the science.

One more thing before we get into the fun stuff. These are the questions you should ask yourself when you want to know if a supplement is worth taking:

Is it safe?

Does it work?

Do its effects justify its cost?

(Modified for brevity from SPEED)

We’ll answer these questions after the scientific research is discussed for each supplement.

Caraway Seeds – First, understand that Dr. Oz promotes these as an anti-bloating aide. While being less bloated is a nice thing, it doesn’t mean you’re any slimmer than you were a week ago. While I could find no research on the effectiveness of caraway seeds as an anti-gas/anti-bloating agent, the seeds may have some antioxidative qualities ( . This research was done on the oil from caraway seeds, but I imagine the seeds themselves would have the same qualities. Should you eat them after a meal to stop gas and bloating? It can’t hurt, I guess. You might do better to find out what food is causing the gas and bloating and eliminate that instead.

Is it safe? Yes.

Does it work? No research available.

Do its effects justify its cost? Maybe.


Raspberry Ketone – we’ve reviewed this supplement previously here.


7-Keto – This one has some research to discuss, so excuse the length of this section. First, for those who are uninterested in understanding the science behind this product, let me just say that I think 7-Keto may help your fat loss efforts, but only minimally so. If you have extra cash you’re looking to burn on a dietary supplement, go ahead and spend it on 7-Keto. If you’d rather save your money and just trust hard work and consistency to do their job, then do that.

The first study, to my knowledge, to look at 7-keto (or 7-oxo-DHEA) is Kalman et al from 2000. This study compared 7-Keto to placebo in subjects eating 1800 calories/day and exercising 3 times/week for 60 minutes. Over 8 weeks, the 7-Keto group lost 2.88kg (6.3 lbs) while the placebo group lost 0.97kg (2.1 lbs). Subjects in the 7-Keto group also experienced a significant rise in triiodothyronine (T3), the most active form of thyroid hormone, without a rise in TSH or T4. The researchers concluded the extra fat loss associated with the 7-Keto group was due to the effects of the supplement and not because the placebo group were a bunch of non-compliant slouches.

Next up, the first of three studies by Zenk et al from 2002. This study compared the use of 7-Keto Naturalean to placebo. The former is a product which contains 7-Keto as well as a few other ingredients the researchers believed to be synergistic to 7-Keto. After 8 weeks, the 7-Keto Naturalean group lost about 2.15 kg compared to a loss of 0.72kg for the placebo group. Levels of all thyroid hormones did not differ between groups, which is in opposition to the findings of Kalman et al. There was also no difference in metabolic rate between groups measured by indirect calorimetry.

The 2nd of 3 from Zenk et al came in 2005, where they compared a weight loss product which contained, among other ingredients, 7-Keto. The researchers found a significant increase in resting metabolic rate (RMR) of 7.2% and a significant difference in hip circumference measurement change in the supplement group when compared to placebo. There is some head-scratching material in this study, however. It’s strange to get a difference in hip circumference when weight, lean tissue and fat tissue levels all changed similarly in both supplement and placebo groups. This is explained by a higher proportion of females in the study population than males, about 70% female. It should be noted that while this formulation elicited a change in RMR, a previous product which included 7-Keto but differing other ingredients did not. The product in this study included a few central nervous system stimulants, including yerba mate and guarana (caffeine). These ingredients may be largely responsible for the increase in metabolic rate.

The 3rd Zenk paper is from 2007 and investigated the effects of both 7-Keto and a formulation containing 7-Keto as compared to placebo. RMR was greater in the formula and 7-Keto groups as compared to placebo, but no differences were found between the formula and 7-Keto (there was a trend for the formula to be higher). No significant changes were found between any group for weight, fat, or lean tissue. It should be noted the formula included green tea extract which may help raise RMR through sympathetic nervous stimulation.

All-in-all, it seems that 7-Keto may help attenuate the drop in RMR seen with weight loss diets, but it seems this effect can be had by good old caffeine or green tea extracts. Combining the two (7-Keto and caffeine) may work synergistically to a greater effect but cost per real world effect is a concern. After all, as stated in this previous post, a bottle of simple caffeine anhydrous can be bought for about $10/100 grams (about 500 servings). I would put 7-Keto on my list of supplements that may help a little bit, but I wouldn’t go out of my way to recommend it. Then again, I don’t have a show on which I need to keep overweight people frothing at the mouth for the next magic bullet.

Is it safe? Yes

Does it work? Yes, but better in combination with other ingredients.

Do its effects justify its cost? Probably not.


Forskolin – There is one study that investigated the effects of forskolin on human body composition in men. The paper by Goddard et al from 2005 administered 250mg of forskolin (10%) twice daily for 12 weeks to 15 subjects and placebo to 15 subjects. The supplement group lost a mean 4.52kg of fat mass and gained 3.71kg of lean mass – get this – with no exercise or dietary changes. Well, at least none reported. In most studies like this one, the paper will specifically say that all subjects were encouraged to keep diet and activity levels the same throughout the study period. While dietary recall was performed, no mention of activity levels was given. There was also an increase in bone mass shown in the supplement group as compared to placebo and  a significant difference in free testosterone in the supplement group over time.

I’ll be honest, I’m skeptical about this one. This seems a little too good to be true although there is some other research in rats showing proposed mechanisms of action for forskolin. I’d love to see more research performed in men with a little tighter control on diet and exercise.

There is one other study investigating the effects of forskolin supplementation in women. To make a long story short : no significant differences were seen in body weight, bone mineral area, bone mineral density, fat mass, lean mass, % body fat, or % body water. Nothing. Nada. Zilch.

Could the difference here be between the sexes? Without further research it’s hard to say.

Is it safe? Yes.

Does it work? Maybe. More research is needed.

Do its effects justify its cost? Maybe in men.


Saffron – One study from 2010 investigated saffron’s ability to reduce snacking in slightly overweight women who were frequent snackers (spell check is telling me snackers is not a real word. It should be). While there was a statistically significant reduction in snacking events after 8 weeks (12.1 to 5.8 vs 12.5 to 8.9 events per 2 weeks in the saffron vs placebo groups, respectively), the reduction in snacking did not result in significant weight loss (only about 1 kg or 2 lbs.) Saffron might help reduce your appetite and so may be helpful paired with a diet and exercise program, but much more research is necessary before I’d give it the green light. Depending on cost, it may be worth experimenting yourself to see if you find it helpful.

Is it safe? Yes

Does it work? Maybe. It needs to be studied with a diet and exercise program.

Do its effects justify its cost? Probably not.



Supplements are called supplements for a reason. The term assumes you have the rest of your healthy lifestyle plan in place. There are just a few supplements that have stood the test of rigorous scientific scrutiny and come out on the other side. We’ve reviewed the evidence for a ton of supplements to figure out which ones we feel are safe, effective and justify the cost and we’ve listed them in the Diet chapter of our book, SPEED. Interestingly, while reviewing the evidence for the above supplements, a substantial amount of research popped up for green tea extract. Will GTE end up on the SPEED Approved Supplements list in the 2nd edition? Who knows?



Godard, M. P., Johnson, B. a, & Richmond, S. R. (2005). Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men. Obesity research, 13(8), 1335-43. doi:10.1038/oby.2005.162

Gout, B., Bourges, C., & Paineau-Dubreuil, S. (2010). Satiereal, a Crocus sativus L extract, reduces snacking and increases satiety in a randomized placebo-controlled study of mildly overweight, healthy women. Nutrition research (New York, N.Y.), 30(5), 305-13. Elsevier Inc. doi:10.1016/j.nutres.2010.04.008

Hasan, I., Ansari, A. H., Sherwani, A. M. K., & Zulkifle, M. (2011). The incredible health benefits of saffron : A Review. Bmc Complementary And Alternative Medicine, 4(7), 2156-2158.

Henderson, S., Magu, B., Rasmussen, C., Lancaster, S., Kerksick, C., Smith, P., Melton, C., et al. (2005). Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight women. Journal of the International Society of Sports Nutrition, 2(2), 54-62. doi:10.1186/1550-2783-2-2-54

Kalman, D. S., Colker, C. M., Swain, M. A., & Torina, G. C. (2000). A Randomized , Double-Blind , Study of 3-Acetyl-7-Oxo-Dehydroepiandrosterone in Healthy Overweight Adults. Current, 61(7).

Kavitha, C., Rajamani, K., & Vadivel, E. (2010). Coleus forskohlii : A comprehensive review on morphology , phytochemistry and pharmacological aspects. Journal Of Medicinal Plants, 4(4), 278-285.

Wu, J.-jung, Wang, K.-lee, Mao, I.-fang, Chen, M.-lien, Hsia, S.-min, & Wang, P. S. (2010). Effects of Oral Nonylphenol on Testosterone Production in Rat Leydig Cells. Blood, 2(1), 47-52. doi:10.4247/AM.2010.ABA001

Zenk, J. L., Frestedt, J. L., & Kuskowski, M. a. (2007). HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. The Journal of nutritional biochemistry, 18(9), 629-34. doi:10.1016/j.jnutbio.2006.11.008

Zenk, J. L., Helmer, T. R., Kassen, L. J., & Kuskowski, M. A. (2002). The Effect of 7-Keto Naturalean on Weight Loss : A Randomized , Double-Blind, Placebo-Controlled Trial. Current Therapeutic Research, 63(4), 263-272.

Zenk, J. L., Leikam, S. a, Kassen, L. J., & Kuskowski, M. a. (2005). Effect of lean system 7 on metabolic rate and body composition. Nutrition (Burbank, Los Angeles County, Calif.), 21(2), 179-85. doi:10.1016/j.nut.2004.05.025

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63 Responses to “Dr. Oz Supplement Round-up: Caraway Seeds, Raspberry Ketone, 7-Keto, Forskolin, Saffron”

  1. [...] on the show? Dr Oz has repeatedly misrepresented the facts on supplements, see Matts posts HERE,  HERE and HERE. What’s the deal Dr.Oz? I thought you were all about giving your audience and [...]

  2. [...] on the show? Dr Oz has repeatedly misrepresented the facts on supplements, see Matts posts HERE,  HERE and HERE. What’s the deal Dr.Oz? I thought you were all about giving your audience and [...]

  3. Bibi Sanchez says:

    I am happy to read this before i buy any.

  4. Sarah says:

    Thank you Jeff and Matt for doing the ‘meta-analysis’ of the studies (or lack thereof) on all these supplements Dr. Oz hypes. I am a physician who normally doesn’t watch Dr. Oz, but I have a weight loss buddy who’s been telling me about the show, so I watched the shows about weight loss for a few weeks. I could not believe all the different supplements he touts as the magic pill for weight loss. I am very disappointed in him. As you pointed out, a responsible physician would read the studies himself and not believe some guy who owns the company that makes the supplement. BTW, you guys impressed me so much that I’ve bought your book.

    • Matt Schoeneberger says:

      Sarah, thank you for that. Let us know what you think of the book when you get through with it.


  5. Marby says:

    Hi Matt, You mentioned that 7 keto works best when taken synergistically with caffeine. Is it okay or should I ask, do you think it is best to combine taking 7 keto with forskolin for weight loss? Please let me know your opinion on this since I have been taking 7 keto for a week now and have not seen or feel any difference yet as far as losing some inches or weight. Is caffeine the only supplement I can combine with 7 keto to at least aid in losing weight? thanks! hoping for your reply soon.

    • Matt Schoeneberger says:


      I would combine 7 Keto with caffeine for weight loss. The evidence for forskolin is not great, and the 7 Keto + caffeine combo seems to work well. Caffeine has tons of evidence for help with weight loss and it’s cheap, so I’m all for it.

      You can add caffeine a few ways: 1. use caffeine anhydrous powder. Be VERY CAREFUL of serving sizes here. Make sure you understand the servings because it takes very little caffeine to get the desired effects and too much caffeine can be dangerous. 2. Look for a supplement that includes 7-Keto and caffeine (either from yerba mate or guarana). 3. Drink coffee or energy drinks that contain caffeine.

      By far the most cost effective of the 3 solutions will be #1.

      Good luck Marby and check back in and tell us how it goes!


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    Thậm chấy, những người mắc bệnh trĩ vày thiếu
    hiểu biết phứt căn bệnh nà mà hở quăng quật trải qua thời khắc “vàng” phanh điều trừng trị bệnh
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    và biểu đạt thứ bệnh, trĩ đặt chia vào tiến đánh 3 loại:
    trĩ ngoại, trĩ nội và trĩ hẩu lốn. trong suốt bài xích viết sau đây chúng tôi sẽ giúp cạc bạn giàu cái nhóng tổng quan tiền nhất phăng bệnh trĩ nội, đơn loại
    trĩ hoi lắm khó chịu và hiểm biếu người bệnh nhất.

    Trĩ nội là bệnh hệt?
    Trĩ nội (Internal hemorrhoids): là bệnh mà cạc búi trĩ phát xuất
    tự những đám xù yên tĩnh mạch bị phùng lên ở đằng trong suốt lỗ đít phía trên lối lược.
    Bệnh trĩ nội phanh chia công 4 vội khoảng:

    vội vàng quãng 1: Búi trĩ phùng lên nhưng mà không lâm vào ngoài.
    Ở vội từng này, người bệnh nhiều trạng
    thái bị chảy ngày tiết lát đại tiện.
    gấp từng 2: Búi trĩ rớt ra ngoài buổi ỉa và tụt vào thẳng
    tính hồi hương trớt khúc.chữa bênh trĩ ngoại
    gấp khoảng 3: Búi trĩ rớt chắc ra ngoài khi
    ỉa. đền rồng nếu dùng tay đẩy vào. chữa bệnh táo bón
    vội vàng dạo 4: Búi trĩ sớt rắn chắc ra ngoài hậu môn, sử
    dụng tay núp ra búi trĩ lại thò ra.
    Trĩ nội tuy là bệnh lành tính hạnh, giò nguy hiểm đến tính mạng cơ mà bởi xuất giờ ở đít vực
    “thầm kín kín”, cuộng cùng dạ lý
    ngại, trinh nữ cơ mà đa số những người mắc trĩ đền rồng giấu giếm bệnh và tự trên dưới cách sửa trừng phạt.
    Chỉ đại hồi bệnh biến làm chứng nặng, ảnh hưởng to tới đả việc,
    cuộc sống thường nhật và hoạt cồn “phòng the”
    thời người bệnh mới bay nhà tù.

    hồi hương nào là bệnh rất khó chữa
    và người bệnh sẽ giàu nguy cơ đắt phải
    một số bệnh lý hậu môn – trực tràng hiểm khác, thậm chí là nếu như
    sống chung cùng trĩ nội cả đời.
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    nghỉ kiêng kị bọn hồi và phình lên,
    gây nên chi trĩ nội. Vì vậy, cồn tác rặn chốc bị táo bón và
    ỉa chảy mãn tính là thó phạm trước nhất hoi vì vậy bệnh
    trĩ nội.
    hoẵng thai và sinh con: đàn bà đem thai trong 6 tháng
    chót thai kỳ cũng dễ đắt bệnh trĩ, duyên cớ là vị sức nhẹ của thai nhi gây giáp lên các mạch máu ở vùng xương chậu khiến biếu danh thiếp huyết quản nào là bị giãn ra.

    Và đụng tác rặn khi sinh em nhỏ là
    “rượu cồn sức” đặt danh thiếp mạch máu nè tạo vách búi trĩ.
    đền thời bệnh trĩ nội trong dài ăn nhập nào là
    sẽ từ bỏ khỏi sau chập chấm dứt kỳ
    thai sản.
    Đứng hay là ngồi lâu một chốn: hồi hương nghiên cứu áp lực tĩnh mạch trĩ,
    người min chộ rằng sức ép tĩnh mạch trĩ là 25cm H2O
    ở phong độ nằm, tăng thóp lên 75cm H2O ở tư thế đứng năng ngồi.
    thành thử, tỉ châu lệ mắc bệnh trĩ nội ở nghề nghiệp nếu đứng lâu, ngồi lắm,
    mỏng trớt lại như thơ ký bàn giấy, nhân viên nửa quán, viên chức
    đả sở, thợ may, thợ bốc tóc…cao hơn những nghề khác.

    Bệnh hậu môn – thường trực tràng khác: mế bướu hậu môn thường trực tràng, ung ấu thơ trực tràng, bưng bướu
    miền tiểu khung… chốc to có dạng chèn lấn và cản ngăn sự lưu thông
    tỏ huyết cụm từ cạc yên tĩnh mạch xung quanh lỗ
    đít công tặng cạc yên tĩnh mạch này căng phùng lên tạo vách bệnh trĩ
    nội. trong suốt những dài ăn nhập
    nà, trĩ nội phanh nhóng là triệu làm chứng mức cạc bệnh trên, vì vậy tã điều
    trị ta giả dụ điều trừng trị duyên cớ
    chẳng chẳng trừng trị như bệnh trĩ.

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    – Dễ dùng
    ♥ thời kì điều trừng phạt bệnh Trĩ Nội :
    Trung bình cỡ 30 ngày.
    Bệnh trĩ nội nhiều những triệu làm chứng gì?

    tung huyết là triệu chứng nhiều sớm nhất và Thường gặp nhất ở tìm kiếm 1 và 2.
    Triệu chứng nào đền rồng rất thầm lặng và người bệnh chỉ phạt bây
    chừ chập chộ huyết ngấm ở giấy rệ sinh năng lộn trong phận lót phứt đi ngoài.
    Càng béng sau máu tan càng nhiều và lắm dạng tia,
    bé giọt hay cục huyết đông. giàu trường học hiệp người bệnh giả dụ chạy vội cứu do tốn máu quá nhiều.

    lâm búi trĩ: Xuất hiện giờ ở trĩ nội lùng 3,
    sau triệu chứng rã tiết và người bệnh sẽ nhiều cảm giác tồn tại dị phẩy ở lỗ đít.
    chốc đầu, sau mỗi một dò ỉa người bệnh
    sẽ thấy có đơn ti tỉ nhỏ lồi vào ở lỗ lã
    lỗ đít và nhiều thể từ bỏ tụt vào đại hồi ỉa đoạn. Càng phai sau ti tỉ lồi đó càng lớn lên và
    chẳng trường đoản cú sụt ra sau hồi đại tiện nữa nhưng mà nếu như sử dụng tay ních ra.
    chung cục khối lồi đó sẽ lâm đứt vào ngoài hậu môn.
    Ngoài 2 triệu làm chứng trên, người bệnh sẽ chộ đau, ngứa và
    ẩm ướt ở khu vực vòng vo hậu môn. Đau có
    tã lót ngồi và chuyển di.
    Biến làm chứng mức bệnh trĩ nội
    Bệnh trĩ nội giả dụ chớ xuể phạt
    hiện nay và điều trừng phạt kịp thời sẽ gây vì thế những
    biến làm chứng nghiêm coi trọng và hiểm nguy như:
    – nghẽn mạch:
    Thường xảy ra ở trĩ ngoại hơn trĩ nội.
    giàu thể là vày vỡ lẽ tĩnh mạch hay là vì giờ tịnh vô đông máu trong suốt dạ huyết quản.
    nhát chiếu tướng lỗ đít sẽ chộ búi trĩ có màu ngơ xanh,
    kích thước lớn hơn hột đỗ, lèn ra thấy căng mọng và
    đau rát. Người bệnh sẽ chộ dễ chịu phải để rạch lấy cục cằn huyết đông ra.

    – Nghẹt:
    lắm dạng nghẹt 1 phần hoặc tuốt tuột hậu môn. Xảy vào lát búi trĩ năng vòng trĩ xa đứt vào ngoài khiến huyết quản bi Tắc và hoi phù nề hà, vì đó không
    thể từ bỏ thụt lại ra trong vâng hậu môn xuể.
    nhút nhát thăm nhà pha sẽ chộ mặt ngoài mực xứ da lòng vòng chốn nghẹt
    giàu màu xám, mặt trong là niêm mạc màu nâu đỏ, sưng nại, rải rác giàu những nốt xám
    mun là vì xuất hiện thời hiện nay tượng hoại tử.

    – Nhiễm khuẩn:
    đền rồng là viêm kẽ, viêm mọc, polyp lỗ đít, nứt kẽ hậu môn….
    hồi hương bị nhiễm khuẩn người bệnh sẽ
    có cảm giác ngứa ngáy hay là lạnh rát.
    chập thăm khám xét người bệnh sẽ chộ rất đau, kia vòng hậu
    môn thít chặt, giãn nở kém. chiểu hậu môn chộ cạc mọc phù
    năn nỉ sưng lớn, màu trắng, cạc kẽ nằm giữa cạc búi trĩ bị loét cạn và giàu
    màu hồng.
    trọng tâm tham mưu và sửa bệnh thuốc nam, chữa bệnh Trĩ Nội khỏi hẳn, chứ tái phạt tuần tra 100% Thảo dược tự nhiên :
    Cách dùng Thuốc : kết hợp 2 loại thuốc : Thuốc Cao và
    Thuốc bao trùm ra huyệt bách hội ( phọt chỏm đầu) .
    Thời gian điều trừng phạt bệnh Trĩ Nội Trung bình tự 20 đến 30 ngày.

    1. Thuốc Cao :
    – mỗi một liệu chừng đệ điều trừng phạt gồm nhiều 2 mẩu
    cao. mỗi một miểng chia 15 phần dùng cho 15 ngày điều trị.
    mỗi một ngày 2 – 3 dò.
    – Hòa vào nác ấm rồi uống ( sau bát)
    2. Thuốc đắp vụt (ng5) chóp đầu ( Huyệt Bách hội) :

    – Thuốc phanh chế biến trường đoản cú Thảo
    dược bá : cần biểu quản ngại trong suốt cản bần tiện phủ rét
    Mỗi giờ hồn đệ thuốc đắp : bệnh
    nhân trớt chia đả 10 phần văn bằng nhau. Mỗi phần dùng biếu 3 ngày điều trị.

    – Cách dùng : đắp thuốc ra phần thót trên đỉnh đầu,
    nhất quyết văn bằng 1 khăn bé. mỗi một ngày trùm 2 dọ, Mỗi
    dọ trường đoản cú 15-20 phút.
    Chú ý : Mỗi phần thuốc sử dụng biếu 3 ngày,
    cho nên sau mỗi một dọ sử dụng đoạn, thuốc cần biểu quản ngại trong ngăn kẹo phủ rét.
    Trước khi dùng 60 phút lấy vào tặng phạng đông, sau đó phun thưa Rượu gạo hững hờ ra thuốc (cho thuốc mềm
    dẻo và lắm đủ kiêng ẩm) rồi bao trùm ra vót.

    – Thuốc trùm nhiều tác dụng : Thăng
    Dương khí, điều trừng trị hiệu quả cạc làm chứng sớt, nện ( Trĩ, rơi lòng con..),đồng thời bồi bổ Tỳ,
    Vị giúp nhuận trường, chống táo bón và cản dự phòng Trĩ tái
    ♥ Kết trái sau điều trừng trị : Bệnh nhân dịp khỏi
    hẳn bệnh Trĩ ( chả đang búi trĩ, không trung đau rát hậu môn, giò ra máu..) và chớ tái
    phân phát.
    ♥ cùng trường học hạp bị bệnh Trĩ Nội
    lâu năm, Thời gian điều trị lắm dạng kéo trường học hơn.
    ♥ quy hàng trăm bệnh nhân dịp bị bệnhTrĩ Nội dùng
    Thuốc thứ trọng tâm hả khỏi hẳn bệnh và đừng tái phát.

    ♥ hoàn trả lại 100% Tiền Thuốc phải bệnh không thuyên giảm.

    - See more at:

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